MARC details
000 -LEADER |
fixed length control field |
05675cam a2200517 i 4500 |
001 - CONTROL NUMBER |
control field |
18674915 |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20220527082421.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
150626s2015 nyua b 001 0 eng c |
010 ## - LIBRARY OF CONGRESS CONTROL NUMBER |
LC control number |
2015944985 |
016 7# - NATIONAL BIBLIOGRAPHIC AGENCY CONTROL NUMBER |
Record control number |
101670814 |
Source |
DNLM |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
9781493929139 |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
1493929135 |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
Canceled/invalid ISBN |
9781493929146 |
020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
International Standard Book Number |
1493929143 |
035 ## - SYSTEM CONTROL NUMBER |
System control number |
(OCoLC)ocn908374534 |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
DNLM |
Language of cataloging |
eng |
Transcribing agency |
NLM |
Description conventions |
rda |
Modifying agency |
BTCTA |
-- |
YDXCP |
-- |
HNK |
-- |
OCLCF |
-- |
OCLCO |
-- |
OCLCQ |
-- |
OCLCO |
-- |
DLC |
042 ## - AUTHENTICATION CODE |
Authentication code |
pcc |
050 00 - LIBRARY OF CONGRESS CALL NUMBER |
Classification number |
QP552.G16 |
Item number |
G126 2015 |
060 00 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
Classification number |
W1 |
Item number |
ME9616J v.1335 2016 |
060 10 - NATIONAL LIBRARY OF MEDICINE CALL NUMBER |
Classification number |
QU 25 |
082 00 - DEWEY DECIMAL CLASSIFICATION NUMBER |
Edition number |
22 |
Classification number |
571 |
130 0# - MAIN ENTRY--UNIFORM TITLE |
Uniform title |
G protein-coupled receptors in drug discovery (Filizola) |
245 10 - TITLE STATEMENT |
Title |
G protein-coupled receptors in drug discovery: methods and protocols / |
Statement of responsibility, etc. |
edited by Marta Filizola. |
250 ## - EDITION STATEMENT |
Edition statement |
Second edition. |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
New York |
Name of publisher, distributor, etc. |
Humana Press |
Date of publication, distribution, etc. |
2015 |
300 ## - PHYSICAL DESCRIPTION |
Extent |
xii, 327 pages : |
Other physical details |
illustrations (many color) ; |
Dimensions |
26 cm. |
490 1# - SERIES STATEMENT |
Series statement |
Methods in molecular biology, |
International Standard Serial Number |
1064-3745 ; |
Volume/sequential designation |
1335 |
490 1# - SERIES STATEMENT |
Series statement |
Springer protocols, |
International Standard Serial Number |
1949-2448 |
500 ## - GENERAL NOTE |
General note |
First edition edited by Wayne R. Leifert. |
504 ## - BIBLIOGRAPHY, ETC. NOTE |
Bibliography, etc. note |
Includes bibliographical references and index. |
505 00 - FORMATTED CONTENTS NOTE |
Title |
Purification of stabilized GPCRs for structural and biophysical analyses / |
Statement of responsibility |
James C. Errey [and others] -- |
Title |
Purification and crystallization of a thermostabilized agonist-bound conformation of the human adenosine A2A receptor / |
Statement of responsibility |
Christopher G. Tate and Guillaume Lebon -- |
Title |
2D projection analysis of GPCR complexes by negative stain electron microscopy / |
Statement of responsibility |
Alys Peisley and Georgios Skiniotis -- |
Title |
Nuts and bolts of CF3 and CH3 NMR towards the understanding of conformational exchange of GPCRs / |
Statement of responsibility |
R. Scott Prosser and Tae Hun Kim -- |
Title |
Single-molecule fluorescence microscopy for the analysis of fast receptor dynamics / |
Statement of responsibility |
Julia Wagner [and others] -- |
Title |
Quantitative multi-color detection strategies for bioorthogonally labeled GPCRs / |
Statement of responsibility |
Minyoung Park [and others] -- |
Title |
Approaches to characterize and quantify oligomerization of GPCRs / |
Statement of responsibility |
Sara Marsango, María José Varela, and Graeme Milligan -- |
Title |
Monitoring G protein activation in cells with BRET / |
Statement of responsibility |
Ikuo Masuho, Kirill A. Martemyanov, and Nevin A. Lambert -- |
Title |
Use of fluorescence indicators in receptor ligands / |
Statement of responsibility |
Kaleeckal G. Harikumar and Laurence J. Miller -- |
Title |
Detection and quantification of intracellular signaling using FRET-based biosensors and high content imaging / |
Statement of responsibility |
Michelle L. Halls [and others] -- |
Title |
Measurement of receptor signaling bias / |
Statement of responsibility |
Terry Kenakin -- |
Title |
Approaches to assess functional selectivity in GPCRs : evaluating G protein signaling in an endogenous environment / |
Statement of responsibility |
Laura M. Bohn, Lei Zhou, and Jo-Hao Ho -- |
Title |
Bioluminescence resonance energy transfer approaches to discover bias in GPCR signaling / |
Statement of responsibility |
Elizabeth K.M. Johnstone and Kevin D.G. Pfleger -- |
Title |
Virus-mediated expression of DREADDs for in vivo metabolic studies / |
Statement of responsibility |
Mario Rossi [and others] -- |
Title |
High-throughput screening for allosteric modulators of GPCRs / |
Statement of responsibility |
Robert L. Bertekap Jr. [and others] -- |
Title |
Radioligand binding assay for an exon 11-associated mu opioid receptor target / |
Statement of responsibility |
Gina F. Marrone, Susruta Majumdar, and Gavril W. Pasternak -- |
Title |
Docking and virtual screening strategies for GPCR drug discovery / |
Statement of responsibility |
Thijs Beuming [and others] -- |
Title |
Dynamic process of drug-GPCR binding at either orthosteric or allosteric sites evaluated by metadynamics / |
Statement of responsibility |
Sebastian Schneider, Davide Provasi, and Marta Filizola -- |
Title |
Experiment-guided molecular modeling of protein-protein complexes involving GPCRs / |
Statement of responsibility |
Irina Kufareva, Tracy M. Handel, and Ruben Abagyan -- |
Title |
Interaction fingerprints and their applications to identify hot spots / |
Statement of responsibility |
Andrés F. Marmolejo [and others]. |
520 ## - SUMMARY, ETC. |
Summary, etc. |
This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical, and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists, and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets.-- |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
G proteins |
General subdivision |
Receptors. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Drug development. |
9 (RLIN) |
13259 |
650 12 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Receptors, G-Protein-Coupled. |
650 22 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Drug Discovery. |
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Drug development. |
Source of heading or term |
fast |
9 (RLIN) |
13259 |
650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
G proteins |
General subdivision |
Receptors. |
Source of heading or term |
fast |
655 #2 - INDEX TERM--GENRE/FORM |
Genre/form data or focus term |
Laboratory Manuals. |
700 1# - ADDED ENTRY--PERSONAL NAME |
Personal name |
Filizola, Marta, |
Relator term |
editor. |
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
Uniform title |
Methods in molecular biology (Clifton, N.J.) ; |
Volume/sequential designation |
v. 1335. |
830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE |
Uniform title |
Springer protocols (Series) |
9 (RLIN) |
8945 |
906 ## - LOCAL DATA ELEMENT F, LDF (RLIN) |
a |
7 |
b |
cbc |
c |
pccadap |
d |
2 |
e |
ncip |
f |
20 |
g |
y-gencatlg |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
Dewey Decimal Classification |
Koha item type |
Books |